Research that measures what works
Dr. Khoshbin is a surgeon-scientist. Alongside his practice, he leads and contributes to research on how hip and knee replacement and trauma surgery can be made safer, more durable, and better measured.
Trained in the University of Toronto's Surgeon Scientist Program and fellowship-trained at the Hospital for Special Surgery and in orthopaedic trauma in Boston, Dr. Khoshbin brings a research lens to everyday surgical questions: which techniques recover faster, which implants last, and how outcomes are best measured from the patient's point of view.
What his research looks at
Hip and knee replacement outcomes
Using large registry and health-outcomes data to study how joint replacement performs over time.
The direct anterior approach
Measuring recovery and results for the muscle-sparing anterior technique and the tools used to perform it.
Revision and complex reconstruction
Improving outcomes when a hip needs to be rebuilt or replaced a second time.
Orthopaedic trauma
Complex lower-limb trauma, including pelvic, acetabular, and fractures around an implant.
Patient-reported outcomes
Capturing how surgery affects pain, function, and quality of life as patients experience it.
Quality improvement
Turning evidence into safer, more consistent care pathways.
Studies underway
Dr. Khoshbin is senior investigator on international randomized controlled trials. Four are currently recruiting at St. Michael's Hospital, each registered on ClinicalTrials.gov. Several ask a shared question in older patients with a fracture: is it better to fix the bone or to replace the joint?
Fixation versus replacement for a fracture next to a knee replacement (pDIFFIR)
A randomized controlled trial in older patients who break the thighbone near an existing knee replacement, a periprosthetic fracture. It compares fixing the fracture with replacing the implant, to learn which gives the better recovery.
ClinicalTrials.gov identifier: NCT05805774
Fixation versus replacement for a broken lower thighbone in older adults (DIFFIR)
A randomized controlled trial in older patients with a fracture of the lower thighbone (distal femur), comparing fixing the fracture with replacing the knee joint. Run with a co-investigator at Mount Sinai Hospital.
ClinicalTrials.gov identifier: NCT04076735
Fixing versus replacing the hip for a socket fracture in older adults
A randomized controlled trial in older patients with an acetabular (hip socket) fracture, comparing open surgical fixation with hip replacement.
ClinicalTrials.gov identifier: NCT03713853
A steroid injection in the opposite knee during knee replacement (COCASTI)
A randomized controlled trial studying whether a corticosteroid injection in the opposite, non-operated knee improves comfort and recovery for patients having a knee replacement.
ClinicalTrials.gov identifier: NCT06809998
Explore the publications
Dr. Khoshbin has authored more than one hundred peer-reviewed papers. A selection is below, and the full, current list is on his profiles.
Survivorship of modern total hip replacement to 30 years.
Pentland V, et al. Lancet. 2026;407:855-866.
View on PubMed →Insurance type and withdrawal of life-sustaining therapy in critically injured trauma patients.
Hoit G, et al. JAMA Network Open. 2024;7(7).
View on PubMed →Wear rates of highly cross-linked polyethylene: a randomized controlled trial of four bearing combinations.
Khoshbin A, et al. JB JS Open Access. 2020;5(2).
View on PubMed →Acute complications and mortality of geriatric knee versus hip fractures: a matched cohort study.
Wolfstadt JI, et al. J Am Acad Orthop Surg. 2021;29(21).
View on PubMed →Age, sex, and race in the prescription of anti-osteoporosis medication after hip fracture.
Hoit G, et al. PLoS One. 2022;17(12).
View on PubMed →The complete list, with citations, is kept on these profiles. His full curriculum vitae is also available here.
Google Scholar
His full list of publications and citations, updated automatically.
View Google Scholar →University of Toronto
His faculty profile in the Division of Orthopaedic Surgery.
View U of T profile →Department of Surgery, U of T
His listing with the Temerty Faculty of Medicine.
View department profile →Coverage of his work
Dr. Khoshbin helped bring same-day hip replacement to St. Michael's Hospital, which, as reported by the hospital, was the first in Toronto to offer same-calendar-day discharge for hip replacement, starting in 2018. The program drew national coverage.
A faster route home after hip replacement
The anterior approach and same-day discharge, and what they mean for recovery.
Read the article →Getting patients back on their feet sooner
National coverage of the front-approach, same-day hip replacement technique.
Read the article →Home with a new hip in 12 hours
How a multidisciplinary team built the same-day discharge program at St. Michael's.
Read the article →Life one year after same-day hip surgery
A patient's recovery a year on from a same-day hip replacement.
Read the article →Leadership and support
- Chair of Research, Canadian Arthroplasty Society (2025).
- Chair of Research, Division of Orthopaedic Surgery, University of Toronto.
- Inaugural Agnico Eagle Chair in Joint Arthroplasty.
- Division Chief of Orthopaedic Surgery, St. Michael's Hospital.
Publication counts, trial details, and profile links on this page are drawn from Dr. Khoshbin's records and public profiles and should be confirmed before publishing.